Endocrine Abstracts

Introduction: Hyponatremia is the most common electrolyte disorder and it affects approximately 5% of adults and 35% of hospitalized patients. Diagnostic and/or therapeutic challenge is given. It is defined by a serum sodium concentration of less than 136 mmol/l. Symptoms of hyponatremia range from mild and nonspecific to severe and life-threatening. Hyponatremia is classified as mild, moderate and severe and may be acute or chronic. Mortality and morbidity are significantly i...

Introduction: Adrenal carcinomas are rare aggressive endocrine tumours with an incidence of 1–1.7 per 1 000 000. Sixty percent of patients present with symptoms of excess hormone secretion, most commonly as hypercortisolism, with or without virilisation due to accompanying androgen secretion. Tumours without clinical hormonal excess most often present with symptoms such as abdominal discomfort or back pain due to tumour growth.Case report: A 72-year...

Context: Hypocortisolism has been associated with increased cardiovascular risk (CVR) and mortality. Higher levels of certain inflammatory markers such as Interleukin-6 (IL6) in patients with adrenal insufficiency (AI) may partly explain the increase in CVR. Recent studies demonstrate an increased prevalence of cardiovascular disease (CVD) in patients with elevated IL-6 levels. Hypocortisolism is generally treated with glucocorticoid replacement therapy (GRT). Current GRT regi...

Introduction: Patients with adrenal insufficiency (AI) are known to have a higher cardiovascular risk (CVR) than the normal population. In particular arteriosclerosis, coronary heart disease, arterial hypertension, hyperlipoproteinemia as well as metabolic disturbances contribute to the increased morbidity and mortality. Aim of this study was to evaluate known cardiovascular risk factors as well as the quality of care by the treating physicians.Material ...

Introduction: A well known side effect of glucocorticoid treatment is abdominally centred weight gain due to increased sensation of hunger but the underlying mechanism is still only incompletely clarified. To elucidate whether the brain reward system is involved in this regulation we studied here the effects of an acute prednisolone infusion on brain centres responding to food stimulation by fMRI in healthy males and correlated these findings to the 24 h food intake of the sub...